Which of the following drugs is known for its capacity to cause severe agitation and paranoia in users?

The drug known for its capacity to cause severe agitation and paranoia in users is amphetamines. This class of stimulant drugs affects neurotransmitters in the brain, particularly dopamine and norepinephrine, leading to increased energy, heightened alertness, and sometimes extreme agitation. Users can experience symptoms such as anxiety, irritability, and paranoia, especially when taken in high doses or over extended periods. The stimulatory effects can lead to a state of hyperarousal, contributing to feelings of paranoia and discomfort.

In contrast, substances like alcohol tend to have a depressant effect on the central nervous system, leading to relaxation and sedation rather than agitation. Cannabinoids, primarily found in cannabis, may cause alterations in perception but generally do not lead to severe agitation or paranoia for most users unless consumed in excessive amounts or by individuals prone to anxiety. LSD, a hallucinogenic substance, primarily affects perception and consciousness, and while it can lead to anxiety in some users, it doesn't typically cause the same level of severe agitation and paranoia associated with amphetamines.