Dependence on amphetamines is likely to develop rapidly when taken how?

Dependence on amphetamines develops more rapidly when taken in large doses intravenously due to the method of administration and the resultant pharmacokinetics. When amphetamines are injected directly into the bloodstream, they produce an intense and immediate euphoric effect, which can reinforce the behavior of use. This rapid onset and peak of effects leads to a greater likelihood of compulsive use as individuals chase the immediate high.

Intravenous use also results in a higher bioavailability compared to other methods of administration, meaning that more of the drug enters the bloodstream and has an effect. This drives a higher risk for developing a psychological dependence, as users may feel compelled to replicate the euphoric experience they initially had. Consequently, the combination of high dosage and rapid administration significantly raises the potential for addiction and dependence.